When I try to use Nvidia DSR, it locks my mouse inside a box that's about one-quarter the size of the actual window. It worked fine before the Edge of Light patch. The only workaround is to set the same DSR resolution for Windows as for the game, but this wasn’t necessary before the patch.
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Can confirm, have the exact same issue. I had a scale factor of 1.78 before, so going back to native resolution is an annoyingly large downgrade.