No. Ammo synths were a bandaid fix to an easily solved problem. Go back and play D1 again and see how bad ammo drops were and how much better they are on D2. In D2 every yellow-bar enemy drops a heavy ammo brick, on D1 heavy ammo is so much rarer, and with Juggler always on on D2, you never run out of kinetic or energy ammo. There's just no need for synths in this game anymore, if there are ammo economy issues, address them properly, don't bandaid fix them...