OK I got my windows 10 to work I ran sfc /scannow and it fixed some file then I went to settings in steam and ran all the check file integrity and where and a few other boxes like location then rebooted the machine and when the anti-cheat box popped up you must accept and install that. then it just loaded right up.
Now my windows 7 machine is still no go it wont load on that and I have tried everything under the sun and it just wont work....
Hope I was some help !
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Same as you, D2 not running since the update, i m use win7 too. I hope Bungie will fix that quickly.